Identification of specific packaging signals in influenza A viruses genome
Identifieur interne : 000371 ( Main/Exploration ); précédent : 000370; suivant : 000372Identification of specific packaging signals in influenza A viruses genome
Auteurs : Marie Gerber [France]Source :
Descripteurs français
- mix :
English descriptors
- mix :
Abstract
The genome of influenza A viruses comprises eight viral RNAs (vRNAs) likely to be selectively packaged into progeny virions as organized supramolecular complexes where vRNAs are held together by base pairing within the packaging signals. To better understand the rules governing this mechanism, we investigated the vRNA/vRNA interaction network of the A/Puerto Rico/8/34 (H1N1) strain. We then identified, at the nucleotide level, using two in vitro approaches, the vRNA sequences involved in several of the interactions. Two of them were functionally tested in an infectious context. We also studied an interaction previously identified in the laboratory between two vRNAs belonging to the circulating A/Moscow/10/99 (H3N2) strain. Finally, we collaborated with Dr L. Brown (Australia) in order to assess the role of an interaction between two vRNAs of the A/Udorn/307/72 (H3N2) strain.
Url:
Affiliations:
Links toward previous steps (curation, corpus...)
- to stream Hal, to step Corpus: 000142
- to stream Hal, to step Curation: 000142
- to stream Hal, to step Checkpoint: 000079
- to stream Main, to step Merge: 000371
- to stream Main, to step Curation: 000371
Le document en format XML
<record><TEI><teiHeader><fileDesc><titleStmt><title xml:lang="en">Identification of specific packaging signals in influenza A viruses genome</title>
<title xml:lang="fr">Recherche de signaux d'empaquetage spécifiques du génome des virus influenza A</title>
<author><name sortKey="Gerber, Marie" sort="Gerber, Marie" uniqKey="Gerber M" first="Marie" last="Gerber">Marie Gerber</name>
<affiliation wicri:level="1"><hal:affiliation type="laboratory" xml:id="struct-93780" status="VALID"> <orgName>Architecture et Réactivité de l'ARN</orgName>
<orgName type="acronym">ARN</orgName>
<desc> <address> <addrLine>Institut de Biologie Moléculaire et Cellulaire 15 rue René Descartes 67084 STRASBOURG Cedex</addrLine>
<country key="FR"></country>
</address>
<ref type="url">http://www-ibmc.u-strasbg.fr/arn/</ref>
</desc>
<listRelation> <relation active="#struct-1956" type="direct"></relation>
<relation active="#struct-199013" type="direct"></relation>
<relation name="FRC1589" active="#struct-441569" type="direct"></relation>
<relation name="UPR9002" active="#struct-441569" type="direct"></relation>
</listRelation>
<tutelles><tutelle active="#struct-1956" type="direct"><org type="regrouplaboratory" xml:id="struct-1956" status="VALID"> <orgName>Institut de biologie moléculaire et cellulaire</orgName>
<orgName type="acronym">IBMC</orgName>
<desc> <address> <addrLine>I.B.M.C. 15 Rue René Descartes 67084 STRASBOURG CEDEX</addrLine>
<country key="FR"></country>
</address>
<ref type="url">http://ibmc.u-strasbg.fr/</ref>
</desc>
<listRelation> <relation active="#struct-199013" type="direct"></relation>
<relation name="FRC1589" active="#struct-441569" type="direct"></relation>
</listRelation>
</org>
</tutelle>
<tutelle active="#struct-199013" type="direct"><org type="institution" xml:id="struct-199013" status="VALID"> <orgName>Université de Strasbourg</orgName>
<orgName type="acronym">UNISTRA</orgName>
<desc> <address> <addrLine>4 rue Blaise Pascal - CS 90032 - 67081 Strasbourg cedex</addrLine>
<country key="FR"></country>
</address>
<ref type="url">http://www.unistra.fr/</ref>
</desc>
</org>
</tutelle>
<tutelle name="FRC1589" active="#struct-441569" type="direct"><org type="institution" xml:id="struct-441569" status="VALID"> <idno type="IdRef">02636817X</idno>
<idno type="ISNI">0000000122597504</idno>
<orgName>Centre National de la Recherche Scientifique</orgName>
<orgName type="acronym">CNRS</orgName>
<date type="start">1939-10-19</date>
<desc> <address> <country key="FR"></country>
</address>
<ref type="url">http://www.cnrs.fr/</ref>
</desc>
</org>
</tutelle>
<tutelle name="UPR9002" active="#struct-441569" type="direct"><org type="institution" xml:id="struct-441569" status="VALID"> <idno type="IdRef">02636817X</idno>
<idno type="ISNI">0000000122597504</idno>
<orgName>Centre National de la Recherche Scientifique</orgName>
<orgName type="acronym">CNRS</orgName>
<date type="start">1939-10-19</date>
<desc> <address> <country key="FR"></country>
</address>
<ref type="url">http://www.cnrs.fr/</ref>
</desc>
</org>
</tutelle>
</tutelles>
</hal:affiliation>
<country>France</country>
<placeName><settlement type="city">Strasbourg</settlement>
<region type="region" nuts="2">Grand Est</region>
<region type="old region" nuts="2">Alsace (région administrative)</region>
</placeName>
<orgName type="university">Université de Strasbourg</orgName>
</affiliation>
</author>
</titleStmt>
<publicationStmt><idno type="wicri:source">HAL</idno>
<idno type="RBID">Hal:tel-01565024</idno>
<idno type="halId">tel-01565024</idno>
<idno type="halUri">https://tel.archives-ouvertes.fr/tel-01565024</idno>
<idno type="url">https://tel.archives-ouvertes.fr/tel-01565024</idno>
<date when="2016-09-27">2016-09-27</date>
<idno type="wicri:Area/Hal/Corpus">000142</idno>
<idno type="wicri:Area/Hal/Curation">000142</idno>
<idno type="wicri:Area/Hal/Checkpoint">000079</idno>
<idno type="wicri:explorRef" wicri:stream="Hal" wicri:step="Checkpoint">000079</idno>
<idno type="wicri:Area/Main/Merge">000371</idno>
<idno type="wicri:Area/Main/Curation">000371</idno>
<idno type="wicri:Area/Main/Exploration">000371</idno>
</publicationStmt>
<sourceDesc><biblStruct><analytic><title xml:lang="en">Identification of specific packaging signals in influenza A viruses genome</title>
<title xml:lang="fr">Recherche de signaux d'empaquetage spécifiques du génome des virus influenza A</title>
<author><name sortKey="Gerber, Marie" sort="Gerber, Marie" uniqKey="Gerber M" first="Marie" last="Gerber">Marie Gerber</name>
<affiliation wicri:level="1"><hal:affiliation type="laboratory" xml:id="struct-93780" status="VALID"> <orgName>Architecture et Réactivité de l'ARN</orgName>
<orgName type="acronym">ARN</orgName>
<desc> <address> <addrLine>Institut de Biologie Moléculaire et Cellulaire 15 rue René Descartes 67084 STRASBOURG Cedex</addrLine>
<country key="FR"></country>
</address>
<ref type="url">http://www-ibmc.u-strasbg.fr/arn/</ref>
</desc>
<listRelation> <relation active="#struct-1956" type="direct"></relation>
<relation active="#struct-199013" type="direct"></relation>
<relation name="FRC1589" active="#struct-441569" type="direct"></relation>
<relation name="UPR9002" active="#struct-441569" type="direct"></relation>
</listRelation>
<tutelles><tutelle active="#struct-1956" type="direct"><org type="regrouplaboratory" xml:id="struct-1956" status="VALID"> <orgName>Institut de biologie moléculaire et cellulaire</orgName>
<orgName type="acronym">IBMC</orgName>
<desc> <address> <addrLine>I.B.M.C. 15 Rue René Descartes 67084 STRASBOURG CEDEX</addrLine>
<country key="FR"></country>
</address>
<ref type="url">http://ibmc.u-strasbg.fr/</ref>
</desc>
<listRelation> <relation active="#struct-199013" type="direct"></relation>
<relation name="FRC1589" active="#struct-441569" type="direct"></relation>
</listRelation>
</org>
</tutelle>
<tutelle active="#struct-199013" type="direct"><org type="institution" xml:id="struct-199013" status="VALID"> <orgName>Université de Strasbourg</orgName>
<orgName type="acronym">UNISTRA</orgName>
<desc> <address> <addrLine>4 rue Blaise Pascal - CS 90032 - 67081 Strasbourg cedex</addrLine>
<country key="FR"></country>
</address>
<ref type="url">http://www.unistra.fr/</ref>
</desc>
</org>
</tutelle>
<tutelle name="FRC1589" active="#struct-441569" type="direct"><org type="institution" xml:id="struct-441569" status="VALID"> <idno type="IdRef">02636817X</idno>
<idno type="ISNI">0000000122597504</idno>
<orgName>Centre National de la Recherche Scientifique</orgName>
<orgName type="acronym">CNRS</orgName>
<date type="start">1939-10-19</date>
<desc> <address> <country key="FR"></country>
</address>
<ref type="url">http://www.cnrs.fr/</ref>
</desc>
</org>
</tutelle>
<tutelle name="UPR9002" active="#struct-441569" type="direct"><org type="institution" xml:id="struct-441569" status="VALID"> <idno type="IdRef">02636817X</idno>
<idno type="ISNI">0000000122597504</idno>
<orgName>Centre National de la Recherche Scientifique</orgName>
<orgName type="acronym">CNRS</orgName>
<date type="start">1939-10-19</date>
<desc> <address> <country key="FR"></country>
</address>
<ref type="url">http://www.cnrs.fr/</ref>
</desc>
</org>
</tutelle>
</tutelles>
</hal:affiliation>
<country>France</country>
<placeName><settlement type="city">Strasbourg</settlement>
<region type="region" nuts="2">Grand Est</region>
<region type="old region" nuts="2">Alsace (région administrative)</region>
</placeName>
<orgName type="university">Université de Strasbourg</orgName>
</affiliation>
</author>
</analytic>
</biblStruct>
</sourceDesc>
</fileDesc>
<profileDesc><textClass><keywords scheme="mix" xml:lang="en"><term>Genome packaging</term>
<term>Influenza A virus</term>
<term>Intermolecular RNA/RNA interaction</term>
<term>Reverse genetics</term>
<term>Viral RNA</term>
</keywords>
<keywords scheme="mix" xml:lang="fr"><term>ARN viraux</term>
<term>Empaquetage du génome</term>
<term>Génétique inverse</term>
<term>Influenzavirus A</term>
<term>Interaction intermoléculaire ARN/ARN</term>
</keywords>
</textClass>
</profileDesc>
</teiHeader>
<front><div type="abstract" xml:lang="en"> <p>The genome of influenza A viruses comprises eight viral RNAs (vRNAs) likely to be selectively packaged into progeny virions as organized supramolecular complexes where vRNAs are held together by base pairing within the packaging signals. To better understand the rules governing this mechanism, we investigated the vRNA/vRNA interaction network of the A/Puerto Rico/8/34 (H1N1) strain. We then identified, at the nucleotide level, using two in vitro approaches, the vRNA sequences involved in several of the interactions. Two of them were functionally tested in an infectious context. We also studied an interaction previously identified in the laboratory between two vRNAs belonging to the circulating A/Moscow/10/99 (H3N2) strain. Finally, we collaborated with Dr L. Brown (Australia) in order to assess the role of an interaction between two vRNAs of the A/Udorn/307/72 (H3N2) strain.</p>
</div>
</front>
</TEI>
<affiliations><list><country><li>France</li>
</country>
<region><li>Alsace (région administrative)</li>
<li>Grand Est</li>
</region>
<settlement><li>Strasbourg</li>
</settlement>
<orgName><li>Université de Strasbourg</li>
</orgName>
</list>
<tree><country name="France"><region name="Grand Est"><name sortKey="Gerber, Marie" sort="Gerber, Marie" uniqKey="Gerber M" first="Marie" last="Gerber">Marie Gerber</name>
</region>
</country>
</tree>
</affiliations>
</record>
Pour manipuler ce document sous Unix (Dilib)
EXPLOR_STEP=$WICRI_ROOT/Sante/explor/H2N2V1/Data/Main/Exploration
HfdSelect -h $EXPLOR_STEP/biblio.hfd -nk 000371 | SxmlIndent | more
Ou
HfdSelect -h $EXPLOR_AREA/Data/Main/Exploration/biblio.hfd -nk 000371 | SxmlIndent | more
Pour mettre un lien sur cette page dans le réseau Wicri
{{Explor lien |wiki= Sante |area= H2N2V1 |flux= Main |étape= Exploration |type= RBID |clé= Hal:tel-01565024 |texte= Identification of specific packaging signals in influenza A viruses genome }}
This area was generated with Dilib version V0.6.33. |